Web16 jul. 2015 · The metabolic machinery is also likely to directly affect T cell migratory events, as T lymphocytes continuously recirculate between different microenvironments (e.g., blood, lymphoid tissues, and peripheral tissues), which might in turn modulate T … WebINTRODUCTION: Estrogen deficiency results in trabecular bone loss, associated with T-cell proliferation in the bone marrow. Insulin-like growth factor I (IGF-I) is involved in the regulation of both bone metabolism and lymphopoiesis. A major part of serum IGF-I is derived from the liver. The aim of the present study was to investigate the role of liver …
Metabolic regulation of T lymphocytes. - Semantic …
Web31 mrt. 2015 · The metabolic regulation of T lymphocytes as a consequence of TCR stimulation has attracted much interest ( 2 – 5 ). It is increasingly appreciated that T cell … WebHere, we show that TGF-β, whose elevated production in some solid tumors is linked to a poor prognosis, interferes with the antigenic activation of human Vγ9Vδ2 T cells in vitro . This regulatory cytokine strongly impairs their cytolytic activity, which is accompanied by the induction of particular phenotypic, transcriptomic and metabolic changes. ptin applications
Metabolic regulation of ferroptosis in the tumor microenvironment
Web27 feb. 2024 · Innate lymphoid cells (ILCs) represent a heterogeneous population of recently discovered immune cells that mirror the functions of adaptive T lymphocytes. However, ILCs are devoid of specific antigen receptors and cellular activation depends on environmental cytokines, rendering them as early regulators of immune responses. Type … Web15 jan. 2013 · Thus, the cooperation of multiple distinct regulatory pathways was needed for the survival and effector differentiation of adoptively transferred tumor-reactive CD8(+) T-cells. Our work defines the immune escape pathways in which simultaneous blockade could yield durable immunotherapeutic responses that can eradicate disseminated leukemia. WebDOI: 10.3389/fimmu.2024.1122063 Corpus ID: 257340154; T regulatory cells metabolism: The influence on functional properties and treatment potential @article{Tomaszewicz2024TRC, title={T regulatory cells metabolism: The influence on functional properties and treatment potential}, author={Martyna Tomaszewicz and Anna … ptin application online