WebOct 1, 2016 · The type of conditioning was not significantly associated with relapse or disease-free survival in multivariable models. However, conditioning regimen was the only factor significantly associated with overall survival: FluMel conditioning was associated with a hazard ratio for death of 2.78 (95% CI, 1.23 to 6.27; P = .014) compared with … WebSurvival correlated with type of donor, but not with the degree of histocompatibility match, age or JAK2V617F-status. In patients with myelofibrosis with sibling donors AHSCT is an effective therapeutic option while AHSCT from unrelated donors with FluMel+ATG conditioning led to high rate of graft failure and limited survival.
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WebMay 24, 2024 · FluMel consisted of fludarabine 150 mg/m 2 with melphalan 140 mg/m 2. FBM adds bis-chlorethyl-nitroso-urea/ carmustine at 200 mg/m 2 for 2 days to the FluMel … WebSep 3, 2024 · The incidence of late graft failure was higher in the FluCy group compared to the FluMel group (11% vs 3%; p=0.035). Multivariate analyses showed that the FluMel regimen was associated with better failure-free survival (hazard ration 0.12; p=0.005). Authors concluded that FluMel conditioning is a promising option for children with … dick cheney military contractor
Fludarabine Melphalan reduced-intensity conditioning allotransplanation ...
WebWe hypothesize that a FluMel conditioning regimen may exacerbate this phenomenon. In other transplant types, melphalan is commonly used as part of fludarabine-based RIC … WebThe aim of this study is to compare clinical outcomes of patients who underwent allogeneic stem cell transplantation (HCT) for myelofibrosis with reduced intensity conditioning (RIC) using either Busulfan Fludarabine (BuFlu), Fludarabine Bis-chlorethyl-nitroso-urea/ carmustine Melphalan (FBM) or Fludarabine Melphalan (FluMel) regimens. WebFemales in the FluMel group took significantly longer to develop elevation of serum follicle-stimulating hormone (FSH) concentrations (>10 iu/l) from the onset of puberty than females in the BuCy group (median 5·2 years vs. 2·7 years respectively, P = 0·0135). dick cheney mailing address