CYP1A1 is one of the main extra-hepatic cytochrome P450 enzymes; it is not regarded as being a major contributor to forming the cited epoxides but could act locally in certain tissues such as the intestine and in certain cancers to do so. See more Cytochrome P450, family 1, subfamily A, polypeptide 1 is a protein that in humans is encoded by the CYP1A1 gene. The protein is a member of the cytochrome P450 superfamily of enzymes. See more Metabolism of xenobiotics and drugs CYP1A1 is involved in phase I xenobiotic and drug metabolism (one substrate of it is theophylline). It is inhibited by hesperetin (a flavonoid found in lime, sweet orange), fluoroquinolones and macrolides and induced by See more • Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (Jan 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including … See more The expression of the CYP1A1 gene, along with that of CYP1A2/1B1 genes, is regulated by a heterodimeric transcription factor that consist … See more Several polymorphisms have been identified in CYP1A1, some of which lead to more highly inducible AHH activity. CYP1A1 See more WebApr 10, 2024 · Cytochrome P450 family 1 subfamily A member 2: 22: 4GQS: CYP2C19: P33261: Cytochrome P450 family 2 subfamily C member 19: 23: 6VLT: CYP2C9: P11712: Cytochrome P450 family 2 subfamily C member 9: 24: 4XRY: CYP2D6: P10635: Cytochrome P450 family 2 subfamily D member 6: 25: 4D7D: CYP3A4: P08684: …
Analysis of the association of CYP450 gene polymorphisms
WebCAH resulting from mutations in CYP11B1 (Cytochrome P450, Family 11, Subfamily B, Member 1), the gene encoding 11β-hydroxylase, represents a rare autosomal Mendelian disorder resulting in abnormal steroid secretion by the adrenal cortex. Unlike CAH resulting from 21-hydroxylase deficiency, this disease is far more common in the Middle East and ... WebSep 22, 2024 · Cancer is a leading cause of death worldwide. Cytochrome P450s (P450s) play an important role in the metabolism of endogenous as well as exogenous substances, especially drugs. Moreover, many P450s can serve as targets for disease therapy. Increasing reports of epidemiological, diagnostic, and clinical research indicate that … bowling green ssa office
National Center for Biotechnology Information
WebHuman Gene Set: KEGG_DRUG_METABOLISM_CYTOCHROME_P450. Standard name. KEGG_DRUG_METABOLISM_CYTOCHROME_P450. Systematic name. M9257. Brief description. Drug metabolism - cytochrome P450. Full description or abstract. Collection. WebOct 12, 2002 · CYP46A1 is an unusual member of the P450 superfamily because it is expressed almost exclusively in neurons of the central nervous system. In these cells, the enzyme converts cholesterol into the oxysterol, 24 S -hydroxycholesterol, which—unlike cholesterol—is freely permeable to the blood-brain barrier. WebNational Center for Biotechnology Information bowling green ss office