WebThe clustered DNA lesions are a characteristic feature of ionizing radiation and are defined as two or more damage sites formed within 20 bps after the passage of a … WebJul 13, 2024 · Clustered damage occurring within 1–2 helical turns can be comprised of ≥2 simple lesions which may be non-DSB oxidative clustered DNA lesions (OCDLs) or clustered DSBs. Strand breaks can also be complex, with additional base lesions comprising “dirty ends”.
Clustered telomeres in phase-separated nuclear condensates …
Webnear to the DNA. • Clustered damage occurs in DNA at sufficiently high frequency to be biologically significant. • Some of the damage may be totally unrepairable. • The … WebJan 4, 2000 · Ionizing radiation also induces closely spaced lesions, including double-strand breaks (DSBs)—two or more SSBs on opposing strands within about 10–20 bp (10, 11)—and has been postulated to produce other clustered damages (), composed of other lesions on both DNA strands.Although such clustered damages have been postulated to … ford truck enthusiast forums
Unrepaired clustered DNA lesions induce chromosome …
Web8 rows · Mar 24, 2024 · Clustered DNA damage is believed to be mainly responsible for the detrimental effects of ionizing ... WebDNA damage but not against cell killing in yeast and mammals. Mutat Res. 2009;665(1-2):37-43. 19. Wirzinger G, Weltje L, Gercken J, Sordyl H. Genotoxic damage ... Formation of clustered DNA damage after high-LET irradiation: a review. J Radiat Res. 2008;49(3): 203-210. 29. Miloshev G, Mihaylov I, Anachkova B. Application of the single cell gel ... WebDec 9, 2024 · Modeling ionizing radiation interaction with biological matter is a major scientific challenge, especially for protons that are nowadays widely used in cancer … embedded browser unity